Dr Antreas Kalli

Dr Antreas Kalli

University Academic Fellow

0113 343 8436

Summary: Antreas is group leader based in LICAP. His group uses computational methodologies to simulate how proteins in cell membranes work and how they interact with their environment.

Location: 5.17 Wellcome Trust Brenner Building, St James's University Hospital

Teaching Commitments: Molecular dynamics simulations, molecular modelling, membrane proteins, membranes, signalling receptors, membrane transporters, red blood cell, T-cell receptor, integrin, signalling, lipids

Overview

Dr Kalli is a University Academic Fellow at the Leeds Institute of Cancer and Pathology. Prior to his current position he was a post-doctoral researcher in the Sansom Group, University of Oxford. During his postdoc he used computational methodologies to study how signalling receptors i.e. integrin and the T-cell receptor are activated. He holds a DPhil (PhD) in Structural Biology from the University of Oxford and has a B.Sc in Physics from the University of Cyprus.

His research applies multi-scale molecular dynamics simulations (i.e. coarse-grained and all-atom) and modelling for the study of the function and of the properties of: i) cell signalling receptors (i.e. integrins and T-cell receptor), ii) red blood cell membrane proteins (e.g. the Band 3 anion transporter) and iii) peripheral proteins that are involved in signal transduction pathways (e.g. talin FERM domain). He is particularly interested in understanding how the aforementioned proteins function at the molecular level and how their function may be regulated by their diverse lipid environment.