Case studies

Effect of Self-Assembling Peptides (SAPs)

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Background

In 2010 credentis ag was founded to commercialise the University of Leeds’ intellectual property in the field of self-assembling peptides (SAPs) for use in dentistry. Successful 'first in man' trials were carried out in the School's Dental Translational and Clinical Research Unit, and a CE mark was awarded in 2012, approving clinical use of the product Curodont ™ Repair in the treatment of early caries.

Concept

Led by Professor Jennifer Kirkham, 'Filling without Drilling' SAP technology was co-invented and taken through to commercial partnership at the School of Dentistry, working with the University's Innovation Knowledge Centre in Medical Technologies. SAPs are rationally designed to produce biomimetic scaffolds that are capable of nucleation of tooth mineral based upon knowledge of the role of proteins in enamel formation.

The project exemplifies the School's strategy in translational research with basic research in biomineralisation being used to inform therapeutic design for patient benefit.

Impact and benefits

Credentis ag now market a range of products based on Leeds' SAP technology as part of the Curodont ™ range. In addition to the original Curodont ™ Repair, the company offer Curodont ™ D'Senz for treatment of tooth sensitivity and Curodont ™ Protect for protection against acid erosion. The company are former winners of the Swiss Technology Award and the Swiss Excellent Product award in 2016, see http://www/credentis.com/en/home/

The ultimate goal is to establish the technology globally, benefiting patients and generating revenue and jobs in the UK and beyond.

Pages in this document

  1. Case Studies
  2. Skeletal Tissue Repair and Regeneration
  3. Innovation of Dental Imaging
  4. ADVOCATE (Added Value for Oral Care)
  5. Effect of Self-Assembling Peptides (SAPs)
  6. Don't Smile - Innovative Research Dissemination
  7. Smile Aider - Patient Public Involvement and Engagement
  8. Advancing the Genetics of Enamel Developmental Abnormalities (AGEnDA)
  9. Modelling Oral Biofilms – Informing Health – From Math To Clinic (MOBIH)