Late Phase Cancer Trials

A word cloud showing the cancer areas we run trials in

Research Leads

Professor Julia Brown
Director LICTR, Co-Director Cancer Division

Professor Walter Gregory
Cancer Methodology Lead

Dr Fiona Collinson
Cancer Clinical Director

Haematological Malignancies

Multiple myeloma

Trial acronym Title Modality Status
ACCoRd (Myeloma XII) A phase III study to determine the role of ixazomib as an augmented conditioning therapy in salvage autologous stem cell transplant (ASCT) and as a post-ASCT consolidation and maintenance strategy in patients with relapsed multiple myeloma Systemic therapy Recruiting
Myeloma XI Randomised comparisons, in myeloma patients of all ages, of thalidomide, lenalidomide, carfilzomib and bortezomib induction combinations, and of lenalidomide and combination lenalidomide vorinostat as maintenance Systemic therapy Follow-up
MERIT MyEloma Renal Impairment Trial. A randomised controlled trial of adjunctive plasma exchange in patients with newly diagnosed multiple myeloma and acute renal failure Systemic therapy Closed
MRC Myeloma IX Myelomatosis therapy trial for patients of all age groups Systemic therapy Closed
MRC Myeloma VII An international phase III randomised trial comparing survival and quality of life after two therapeutic approaches in young patients with myelomatosis: ABCM for plateau induction with ?-Interferon maintenance versus a three-phase regimen of C-VAMP, high dose melphalan (with autologous bone marrow/peripheral blood stem cell support as appropriate) and ?-Interferon maintenance Systemic therapy Closed
Myeloma X A phase III study to determine the role of a second autologous stem cell transplant as consolidation therapy in patients with relapsed multiple myeloma following prior high-dose chemotherapy and autologous stem cell rescue Systemic therapy Closed

Chronic lymphocytic leukaemia

Trial acronym Title Modality Status
FLAIR Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab Systemic therapy Recruiting
ADMIRE Does the ADdition of Mitoxantrone Improve REsponse to FCR chemotherapy in patients with CLL Systemic therapy Follow-up
ARCTIC Attenuated dose Rituximab with ChemoTherapy In CLL Systemic therapy Follow-up
CLL207 Eradication of minimal residual disease (MRD) in patients with chronic lymphocytic leukaemia (CLL) with alemtuzumab: A phase II study Systemic therapy Follow-up
COSMIC Combination FC plus Ofatumumab at Standard or Mega dose In CLL Systemic therapy Follow-up
GALACTIC GA-101 (obinutuzumab) monocLonal Antibody as Consolidation Therapy In CLL Systemic therapy Follow-up

Solid tumours

Gastro-intestinal cancers (including colorectal, gastro-oesophageal & anal cancers)

Trial acronym  Title  Modality  Status
GO-2 Alternative chemotherapy for frail or elderly patients with advanced gastric or oesophageal cancer Systemic therapy Recruiting
321-GO Three, two or one-drug chemotherapy for advanced gastroesophageal cancer: a feasibility study in frail and/or elderly patients Systemic therapy Closed
PICCOLO A randomised clinical trial of treatment for fluorouracil-resistant advanced colorectal cancer comparing standard single-agent irinotecan versus irinotecan plus panitumumab* and versus irinotecan plus ciclosporin** (*(in patients with K-RAS wild type tumours), **(in patients with K-RAS mutated or undefined tumours)) Systemic therapy Closed
EMT2 A randomised placebo-controlled phase III trial of the effect of the omega-3 fatty acid eicosapentaenoic acid (EPA) on colorectal cancer recurrence and survival after surgery for resectable liver metastases Systemic therapy / Surgery Set-up
PLATO PersonaLising Anal cancer RadioTherapy dOse – Anal cancer trials (ACT) Radiotherapy Recruiting
GLISTEN 5-ALA in Bowel Cancer Surgery Next Generation intraoperative Lymph node staging for Stratified colon cancer surgery - Developmental phase Surgery Recruiting
LACES A multicentre, randomised controlled feasibility trial of Laparoscopic versus Open Colorectal Surgery in the Acute Setting Surgery Recruiting
SAFARI Sacral nerve stimulation versus the FENIXTM magnetic sphincter augmentation for adult faecal incontinence: a Randomised Investigation Surgery Recruiting
ROLARR RObotic versus LAparoscopic Resection for Rectal cancer Surgery Follow-up
MRC CLASICC MRC Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer Trial Surgery Closed

Urological

Trial acronym  Title  Modality Status
EORTC 30994 Randomised phase III trial comparing immediate versus deferred chemotherapy after radical cystectomy in patients with pT3-pT4, and/or N+M0 transitional cell carcinoma (TCC) of the bladder Systemic therapy Closed
BRAVO BRAVO: High grade Bladder cancer: A randomised controlled trial of Radical Cystectomy against intra-vesical immunotherapy – A feasibility study Systemic therapy / Surgery Recruiting
STAR A Randomised Multi-Stage Phase II/III Trial of Standard first-line therapy (sunitinib or pazopanib) Comparing Temporary Cessation with Allowing Continuation, in the treatment of locally advanced and/or metastatic Renal Cancer Systemic therapy / Surgery Recruiting
SPIRIT This international trial aims to compare radical prostatectomy with brachytherapy for patients with early stage prostate cancer Radiotherapy / Surgery Closed

Lung

Trial acronym  Title  Modality  Status
DART Does Amifosting Reduce Toxicity? A randomized trial of amifostine as a cytoprotective agent in patients receiving chemotherapy for small cell lung cancer Systemic therapy Closed
SABRTOOTH A study to determine the feasibility and acceptability of conducting a Phase III randomised controlled trial comparing stereotactic Ablative Radiotherapy (SABR) with surgery in paTients with peripheral Stage I nOn-small cell lung cancer (NSCLC) cOnsidered To be at Higher risk of complications from surgical resection. Radiotherapy Trial Surgery Trial Follow-up
BLT-QoL Study The main international phase III Big Lung Trial, co-ordinated by the CRUK & UCL Clinical Trials Centre in London, aims to assess whether the addition of cisplatin-based chemotherapy to standard treatment for patients with non-small cell lung cancer improves survival. The primary objective of the QOL study is to investigate differences in the scores for global QOL at 12 weeks between patients receiving supportive care and those receiving supportive care with chemotherapy Methodology – Psychosocial Closed

Melanoma

Brain

Others (including neuroendocrine cancers, thyroid cancer)

Trial acronym  Title  Modality  Status
AZURE Does Adjuvant Zoledronic acid redUce REcurrence in patients with high-risk, localised breast cancer? Systemic therapy Follow-up
LOTUS An international multi-centre long term follow up study of efficacy and safety of use of adjuvant bevacizumab in “triple negative” breast cancer Systemic therapy Follow-up
 MML201 A phase II study of 5-azacitidine in chronic myelomonocytic leukaemia Systemic therapy Closed
ABC Adjuvant endocrine therapy and chemotherapy in women with early breast cancer Systemic therapy Closed
ATAC An international phase III randomised, double-blind trial comparing Arimidex (aromatase inhibitor), Nolvadex (AstraZeneca’s brand name for tamoxifen-antioestrogen) or a combination of both Systemic therapy Closed
BIG-198 An international randomised phase III trial to evaluate letrozole as adjuvant endocrine therapy for postmenopausal women with receptor (ER and/or PgR) positive tumours. Systemic therapy Closed
Bismark Effective use of BISphosphonates in metastatic bone disease – a comparison of bone MARKer directed Zoledronic Acid therapy to standard schedule Systemic therapy Closed
ESTEeM Endocrine +/- Surgical Therapy for Elderly women with Mammary cancer Systemic therapy / Surgery Closed
GBG26 TBP A multi-centre randomised phase III study to compare Capecitabine alone or in combination with trastuzumab in patients with HER2 positive metastatic breast cancer and progression after previous treatment with trastuzumab (Treatment Beyond Progression, TBP Systemic therapy Closed
HERA An international randomised three-arm multi-centre comparison of one year and two years of Herceptin versus no Herceptin in women with HER2-positive primary breast cancer who have completed adjuvant chemotherapy Systemic therapy Closed
IES Intergroup Exemestane Study. A randomised double-blind trial in post-menopausal women with primary breast cancer who have received adjuvant tamoxifen for 2-3 years, comparing subsequent adjuvant exemestane treatment with further tamoxifen Systemic therapy Closed
LANTERN A randomised phase II screening trial with functional imaging and patient reported toxicity sub-studies comparing lapatinib plus capecitabine versus continued trastuzumab plus capecitabine after local therapy in patients with ErbB2 positive metastatic breast cancer developing brain metastasis/es Systemic therapy Closed
SIOPEL1 An international observational study to improve survival and reduce operative morbidity and mortality in children with primary epithelial liver tumours by using combination pre-operative chemotherapy (doxorubicin and cisplatin = PLADO) Systemic therapy Closed
TACT A national phase III randomised trial which aims to identify whether a relapse-free and overall survival benefit can be seen in the adjuvant treatment of women with early breast cancer by the addition of four cycles of sequential docetaxel following four cycles of FEC, when compared with a standard anthracycline regimen of similar overall duration Systemic therapy Closed
TACT2 Trial of Accelerated Adjuvant ChemoTherapy with Capecitabine in Early Breast Cancer (TACT2) Systemic therapy Closed
TANGO A national phase III randomised trial which aims to identify whether the addition of Gemcitabine to Paclitaxel-containing Epirubicin-based adjuvant chemotherapy improves disease-free survival, overall survival and toxicity in patients with ER/PgR-poor, early stage breast cancer Systemic therapy Closed
LAVA Thermal Ablation versus Surgery for Patients with Colorectal Liver Metastases Surgery Set-up
TRaCIng Trial of Remote Continuous vs Intermittent Vital Signs Monitoring after Major Surgery Surgery Set-up
ITS An international observational study to determine whether the timing of the first surgical intervention (ie. excision biopsy, wide local excision or mastectomy) in relation to the phase of the menstrual cycle, has an independent influence on survival, and to investigate the nature of this effect Surgery Closed

Treatment modalities

Systemic therapies (including targeted agents and immunotherapies)

Trial Acronym Title
Disease Area Status
ACCoRd (Myeloma XII) A phase III study to determine the role of ixazomib as an augmented conditioning therapy in salvage autologous stem cell transplant (ASCT) and as a post-ASCT consolidation and maintenance strategy in patients with relapsed multiple myeloma Multiple Myeloma Recruiting
Myeloma XI Randomised comparisons, in myeloma patients of all ages, of thalidomide, lenalidomide, carfilzomib and bortezomib induction combinations, and of lenalidomide and combination lenalidomide vorinostat as maintenance Multiple Myeloma Follow-up
MERIT MyEloma Renal Impairment Trial. A randomised controlled trial of adjunctive plasma exchange in patients with newly diagnosed multiple myeloma and acute renal failure Multiple Myeloma Closed
MRC Myeloma IX Myelomatosis therapy trial for patients of all age groups Multiple Myeloma Closed
MRC Myeloma VII An international phase III randomised trial comparing survival and quality of life after two therapeutic approaches in young patients with myelomatosis: ABCM for plateau induction with ?-Interferon maintenance versus a three-phase regimen of C-VAMP, high dose melphalan (with autologous bone marrow/peripheral blood stem cell support as appropriate) and ?-Interferon maintenance Multiple Myeloma Closed
Myeloma X A phase III study to determine the role of a second autologous stem cell transplant as consolidation therapy in patients with relapsed multiple myeloma following prior high-dose chemotherapy and autologous stem cell rescue Multiple Myeloma Closed
FLAIR Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab Chronic Lymphocytic Leukaemia Recruiting
ADMIRE Does the ADdition of Mitoxantrone Improve REsponse to FCR chemotherapy in patients with CLL Chronic Lymphocytic Leukaemia Follow-up
ARCTIC Attenuated dose Rituximab with ChemoTherapy In CLL Chronic Lymphocytic Leukaemia Follow-up
CLL207 Eradication of minimal residual disease (MRD) in patients with chronic lymphocytic leukaemia (CLL) with alemtuzumab: A phase II study Chronic Lymphocytic Leukaemia Follow-up
COSMIC Combination FC plus Ofatumumab at Standard or Mega dose In CLL Chronic Lymphocytic Leukaemia Follow-up
GALACTIC GA-101 (obinutuzumab) monocLonal Antibody as Consolidation Therapy In CLL Chronic Lymphocytic Leukaemia Follow-up
EMT2 A randomised placebo-controlled phase III trial of the effect of the omega-3 fatty acid eicosapentaenoic acid (EPA) on colorectal cancer recurrence and survival after surgery for resectable liver metastases Gastrointestinal Cancer Set-up
GO-2 Alternative chemotherapy for frail or elderly patients with advanced gastric or oesophageal cancer Gastrointestinal Cancer Recruiting
321-GO Three, two or one-drug chemotherapy for advanced gastroesophageal cancer: a feasibility study in frail and/or elderly patients Gastrointestinal Cancer Closed
PICCOLO A randomised clinical trial of treatment for fluorouracil-resistant advanced colorectal cancer comparing standard single-agent irinotecan versus irinotecan plus panitumumab* and versus irinotecan plus ciclosporin** (*(in patients with K-RAS wild type tumours), **(in patients with K-RAS mutated or undefined tumours)) Gastrointestinal Cancer Closed
BRAVO BRAVO: High grade Bladder cancer: A randomised controlled trial of Radical Cystectomy against intra-vesical immunotherapy – A feasibility study Urological Cancer Recruiting
STAR A Randomised Multi-Stage Phase II/III Trial of Standard first-line therapy (sunitinib or pazopanib) Comparing Temporary Cessation with Allowing Continuation, in the treatment of locally advanced and/or metastatic Renal Cancer Urological Cancer Recruiting
EORTC 30994 Randomised phase III trial comparing immediate versus deferred chemotherapy after radical cystectomy in patients with pT3-pT4, and/or N+M0 transitional cell carcinoma (TCC) of the bladder Urological Cancer Closed
DART Does Amifosting Reduce Toxicity? A randomized trial of amifostine as a cytoprotective agent in patients receiving chemotherapy for small cell lung cancer Lung Closed
Better B A feasibility study of the use of mirtazapine for refractory breathlessness Palliative care Open
AZURE Does Adjuvant Zoledronic acid redUce REcurrence in patients with high-risk, localised breast cancer? Others Follow-up
LOTUS An international multi-centre long term follow up study of efficacy and safety of use of adjuvant bevacizumab in “triple negative” breast cancer Others Follow-up
ABC Adjuvant endocrine therapy and chemotherapy in women with early breast cancer Others Closed
ATAC An international phase III randomised, double-blind trial comparing Arimidex (aromatase inhibitor), Nolvadex (AstraZeneca’s brand name for tamoxifen-antioestrogen) or a combination of both Others Closed
BIG-198 An international randomised phase III trial to evaluate letrozole as adjuvant endocrine therapy for postmenopausal women with receptor (ER and/or PgR) positive tumours. Others Closed
Bismark Effective use of BISphosphonates in metastatic bone disease – a comparison of bone MARKer directed Zoledronic Acid therapy to standard schedule Others Closed
ESTEeM Endocrine +/- Surgical Therapy for Elderly women with Mammary cancer Others Closed
GBG26 TBP A multi-centre randomised phase III study to compare Capecitabine alone or in combination with trastuzumab in patients with HER2 positive metastatic breast cancer and progression after previous treatment with trastuzumab (Treatment Beyond Progression, TBP Others Closed
HERA An international randomised three-arm multi-centre comparison of one year and two years of Herceptin versus no Herceptin in women with HER2-positive primary breast cancer who have completed adjuvant chemotherapy Others Closed
IES Intergroup Exemestane Study. A randomised double-blind trial in post-menopausal women with primary breast cancer who have received adjuvant tamoxifen for 2-3 years, comparing subsequent adjuvant exemestane treatment with further tamoxifen Others Closed
LANTERN A randomised phase II screening trial with functional imaging and patient reported toxicity sub-studies comparing lapatinib plus capecitabine versus continued trastuzumab plus capecitabine after local therapy in patients with ErbB2 positive metastatic breast cancer developing brain metastasis/es Others Closed
SIOPEL1 An international observational study to improve survival and reduce operative morbidity and mortality in children with primary epithelial liver tumours by using combination pre-operative chemotherapy (doxorubicin and cisplatin = PLADO) Others Closed
TACT A national phase III randomised trial which aims to identify whether a relapse-free and overall survival benefit can be seen in the adjuvant treatment of women with early breast cancer by the addition of four cycles of sequential docetaxel following four cycles of FEC, when compared with a standard anthracycline regimen of similar overall duration Others Closed
TACT2 Trial of Accelerated Adjuvant ChemoTherapy with Capecitabine in Early Breast Cancer (TACT2) Others Closed
TANGO A national phase III randomised trial which aims to identify whether the addition of Gemcitabine to Paclitaxel-containing Epirubicin-based adjuvant chemotherapy improves disease-free survival, overall survival and toxicity in patients with ER/PgR-poor, early stage breast cancer Others Closed

Radiotherapy

Trial Acronym Title Disease Area Status
PLATO PersonaLising Anal cancer RadioTherapy dOse – Anal cancer trials (ACT) Gastrointestinal Cancer Recruiting
SPIRIT This international trial aims to compare radical prostatectomy with brachytherapy for patients with early stage prostate cancer Urological Cancer Closed
SABRTOOTH A study to determine the feasibility and acceptability of conducting a Phase III randomised controlled trial comparing stereotactic Ablative Radiotherapy (SABR) with surgery in paTients with peripheral Stage I nOn-small cell lung cancer (NSCLC) cOnsidered To be at Higher risk of complications from surgical resection. Lung Follow-up

Surgery (including devices)

Trial Acronym Title Disease Area Status
EMT2 A randomised placebo-controlled phase III trial of the effect of the omega-3 fatty acid eicosapentaenoic acid (EPA) on colorectal cancer recurrence and survival after surgery for resectable liver metastases Gastrointestinal Cancer Set-up
GLISTEN 5-ALA in Bowel Cancer Surgery Next Generation intraoperative Lymph node staging for Stratified colon cancer surgery - Developmental phase Gastrointestinal Cancer Recruiting
LACES A multicentre, randomised controlled feasibility trial of Laparoscopic versus Open Colorectal Surgery in the Acute Setting Gastrointestinal Cancer Recruiting
SAFARI Sacral nerve stimulation versus the FENIXTM magnetic sphincter augmentation for adult faecal incontinence: a Randomised Investigation Gastrointestinal Cancer Recruiting
ROLARR RObotic versus LAparoscopic Resection for Rectal cancer Gastrointestinal Cancer Follow-up
MRC CLASICC MRC Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer Trial Gastrointestinal Cancer Closed
BRAVO BRAVO: High grade Bladder cancer: A randomised controlled trial of Radical Cystectomy against intra-vesical immunotherapy – A feasibility study Urological Cancer Recruiting
STAR A Randomised Multi-Stage Phase II/III Trial of Standard first-line therapy (sunitinib or pazopanib) Comparing Temporary Cessation with Allowing Continuation, in the treatment of locally advanced and/or metastatic Renal Cancer Urological Cancer Recruiting
SPIRIT This international trial aims to compare radical prostatectomy with brachytherapy for patients with early stage prostate cancer Urological Cancer Closed
LAVA Thermal Ablation versus Surgery for Patients with Colorectal Liver Metastases Others Set-up
TRaCIng Trial of Remote Continuous vs Intermittent Vital Signs Monitoring after Major Surgery
Others Set-up
ESTEeM Endocrine +/- Surgical Therapy for Elderly women with Mammary cancer Others Closed
ITS An international observational study to determine whether the timing of the first surgical intervention (ie. excision biopsy, wide local excision or mastectomy) in relation to the phase of the menstrual cycle, has an independent influence on survival, and to investigate the nature of this effect Others Closed