Dr Nicolas Orsi

Senior Research Fellow

0113 343 8624

Summary: I am joint leader of the Women’s Health Research Group in LICAP.

Location: Room 4.15 Level 4 Wellcome Trust Brenner Building

Overview

After graduating in Animal Science (University of Reading), I pursued my combined interests in biochemistry and reproduction at the University of York under Professor Leese where my PhD focussed on the cellular stresses affecting oocytes and embryos during assisted reproduction in various mammalian species. Thereafter, I joined the Academic Unit of Obstetrics at the University of Leeds where, as a Research Fellow, I worked on the role played by cytokines in various obstetric disorders, in particular pre-eclampsia and premature labour. I pursued this theme actively over subsequent years as a Senior Research Fellow, developing an interest in the mathematical modelling of cytokine networks. At this point, the team’s move into the department of Pathology at Leeds offered the opportunity to branch out into other gynaecological disorders, principally endometrial cancer, which remains a key area of activity to this day.

It was at this stage that I felt that much of my work would benefit from a stronger clinical viewpoint and, whilst remaining research-active, I undertook an MBChB (Medicine) at the University of Leeds which subsequently allowed me to start my training towards becoming an academic gynaecologic pathologist. By this point, the team had developed a broad research portfolio based on numerous international collaborations focussing on an array of gynaecological conditions, systems biology-based approaches to modelling cytokine networks, obstetric complications and their perinatal sequelae, the pathophysiology of gynaecological malignancies and general paediatric disorders. The common theme uniting these different clinical areas is our interest in the role of inflammatory mediators (cytokines, eicosanoids) in pathology.