Dr Darren Newton

Senior Tenure-Track Research Fellow

+44(0)113 343 8031

Summary: I lead the LICAP Clonal Evolution group.

Location: Wellcome Trust Brenner Building, Room 6.13a

Overview

Dr Newton's research interests are primarily in the immunological repertoire and applications of next generation sequencing.

Dr Newton originally graduated with a BSc in Molecular Biology from the University of Liverpool in 1993. Specialising in immunology led onto a PhD investigating T cell signalling, in particular expression of the signalling molecule CD3-ζ.

Dr Newton moved to Leeds in 2002 to take up a postdoctoral position in the laboratory of Professor Simon Carding, focusing on the role of γδ T cells in infection and developed assays to look at the immunological diversity within these cells.

Sequencing and assessment of diversity were also central to his next role in the Haematological Malignancy Diagnostic Service (HMDS) and Section of Experimental Haematology, developing tools to look at intraclonal heterogeneity in Chronic Lymphocytic Leukaemia (CLL). This role expanded to include the use of Next Generation Sequencing platforms (Illumina and 454) to investigate mutation development and the B and T cell immunological repertoires in a number of other conditions.

Developing this work, through successful grant applications, enabled Dr Newton to take up his current role as Senior Research Fellow and to expand on previous work to look at bone marrow failure and, in particular, Paroxysmal Nocturnal Haemoglobinuria (PNH).