Professor Robert Ariëns

Professor Robert Ariëns

Interim Head of DCDR, Wellcome Trust Investigator, and H. C. Hemker Visiting Professor (Maastricht).

0113 343 7734

Summary: Molecular mechanisms in haemostasis and thrombosis.

Location: Division of Cardiovascular and Diabetes Research

Teaching Commitments: PhD supervisor; BSc supervisor; Intercalated Cardiovascular BSc - Mechanisms of Thrombosis Lecture and Research Project Supervisor; Introduction to Medical Science - Blood and Innate Immunology Lectures; Research Skills and Special Studies - Research Project.

Overview

Qualifications

BSc (Utrecht, The Netherlands), PhD (Maastricht, The Netherlands)

Research Area

My research is focused on elucidating novel mechanisms involved in haemostasis and thrombosis. Our main objectives are to discover the molecular mechanisms that regulate the structure of the blood clot, its mechanical properties and its resistance to fibrinolysis. We study naturally occurring variants of protein involved in clot formation (fibrinogen, factor XIII), and investigate the (patho-)physiological mechanisms involved in the formation of the blood clot. Patients with thrombosis have a denser clot structure with smaller pores, altered mechanical properties and resistance to fibrinolysis. My aim is to decipher the mechanisms that lead to these alterations.

Our studies make use of a mixture of molecular biology (recombinant protein expression), biochemistry (purification of proteins from plasma and other sources) and biophysical methods (atomic force microscopy, magnetic tweezers and other methods), combined with clinical studies and studies using models of thrombosis or bleeding. Our work is published in international, high-impact journals such as Lancet, Blood, Circulation, ATVB, JBC, JTH and Biophys J. I collaborate with a number of overseas colleagues in the USA, The Netherlands, Portugal, Hungary and Switzerland. Ultimately the aim of my research is to develop novel treatment options for patients with cardiovascular disease.

I was elected President for the International Fibrinogen Research Society in 2013, am a member of the Editorial Board of the Journal of Thrombosis and Haemostasis, President of the British Society on Haemostasis and Thrombosis since 2016 and served as Chair of the ISTH Factor XIII and Fibrinogen Subcommittee in 2002-2006.

Widening Participation

Our new BHF research programme featured in the Yorkshire Post and Yorkshire Evening Post, July 2013.

I discussed thrombosis on live Sky television (Chrissy B show), August 2013.

Our research on Abdominal Aortic Aneurysms featured in the Yorkshire Post of March 9th, 2011.