Professor Geoffrey Ian Sandle

Professor of Clinical Science, Consultant Gastroenterologist (LTHT)

0113 206 8607

Summary: Clinical Academic Gastroenterolgoist

Location: Room 7.14, Clinical Sciences Building

Overview

After graduating BSc (Hons 2i), Biochemistry in Relation to Medicine (1968) and MB ChB (1971) from University of Leeds, trained in general medicine and gastroenterology in Manchester and Newcastle-upon-Tyne (1973-1978), including the use of multilumen tubes for small intestinal perfusion to study sugar, electrolyte and water absorption, and drug absorption, in controls and patients with coeliac disease. Research Associate, Division of Digestive Diseases, Yale University (1980-1981), developing intracellular microelectrodes to study factors influencing ion transport across mammalian colon. National Foundation for Crohn’s and Colitis Research Fellow, Division of Digestive Diseases, Yale University (1982-1983), extending electrophysiological techniques to study fluid and electrolyte transport on controls and patients with ulcerative colitis. MRC Senior Clinical Fellow (1983-1989) in Newcastle-upon-Tyne (until 1984) and then University Department of Medicine, Hope Hospital, Salford, continuing studies of ion transport in mammalian and human colon using intracellular microelectrode and patch clamp recording techniques. Studies continued while Senior Lecturer in Medicine, University of Manchester (1989-1998) and then NHS consultant gastroenterologist in Leeds (1998-2000).

Awarded promotional Chair in Clinical Science in 2000, and continued to combine electrophysiological and molecular biological techniques to study human colonic ion transport physiology and pathophysiology. One of only a handful of clinician/physiologists with expertise of ion channel physiology in human colon in health and disease.

Currently performing translational research into the pathogenetic mechanisms of diarrhoea and hypoxia-induced changes in intestinal permeability, with the aims of identifying new approaches to the treatment of a variety of diarrhoeal diseases and preventing/reducing the likelihood of sepsis following liver surgery. Collaborated extensively with Prof H J Binder (Yale), and presently have active collaborations with Prof V M Rajendran (University of West Virginia, USA), as well as Professor J P A Lodge (Surgery) and Professor K A MacLennan (Molecular Histopathology) in Leeds.