Section of Experimental Haematology

Led by Professor Peter Hillmen

Research in the Section of Experimental Haematology focuses on haematological malignancies and bone marrow failure syndromes. We employ a range of model systems, primary tissue samples and both single cell and “omics” approaches to analyse the response of cells to novel therapeutic agents, immunological and mutational causes of disease and the events controlling lineage commitment and cell differentiation in the blood and immune system. We are actively involved in the development of novel biomarkers to guide clinical decision making.

We enjoy strong links with the Clinical Haematology Department and Haematological Malignancy Diagnostic Service (http://www.hmds.info/) at Leeds Teaching Hospitals NHS Trust, as well as other partners in the Haematological Malignancy Research Network (http://www.hmrn.org/) of Yorkshire and Humberside.

A principle collaboration with several groups in the Section in relation to the development of systems level and genomic approaches to disease and diagnosis is with the Westhead Lab in the Faculty of Biological Sciences.

Groups

Molecular Haematopathology Research Group
Group Leader: Dr Reuben Tooze

Myeloid Differentiation Research Group
Group Leader: Dr Peter Laslo

Chromatin structure and differentiation Research Group
Group Leader: Dr Pascal Lefevre

Molecular Immunology Research Group
Group Leader: Dr Gina Doody

Clonal Evolution Research Group
Group Leader: Dr Darren Newton

Translational Haematology Research Group
Group Leader: Professor Peter Hillmen

Molecular Haematology Research Group
Group Leader: Professor Ulf Klein