Methodological Research

The CTRU has an active portfolio and strong track record of methodological research being. We are an international leader in psychosocial oncology and have a developing portfolio of statistical methodology research and research into patient reported outcomes. The research strategy underpins the clinical trials research portfolio and has been built upon the Department of Health core funding and strengthened through the University of Leeds and Leeds Teaching Hospitals Trust core funding.

Development of outcome measures underpins our clinical trials research in pressure ulcer prevention and obesity, forming part of a strategic approach to the development of the obesity and skin portfolios.

Importantly the methodological division provides PhD and post-doctoral opportunities and national and international collaboration. A number of outputs from our methodological research are available as downloads.

Click on the titles below for more information.

Cancer Division Methodological Research

  • Design & analysis - adding an arm to an ongoing trial
  • Choice & optimising the size of PhII trials
  • Design & analysis - incorporating surrogate outcomes
  • Statistical modelling - quantifying residual disease and regrowth after treatment
  • Appropriate analysis of cut-points for prognostic variables
  • Adjusting survival curves for confounding effects of subsequent therapy
  • Sample size & design - interventions using biomarker monitoring
  • Design - QALYs as a primary outcome measure
  • Development & use of patient reported outcome measures
  • Psychosocial oncology

Complex Intervention Division Methodological Research  

  • Clustering & multilevel data structures
  • Design & analysis - early phase studies including feasibility and pilots
  • Development & appraisal of outcome and outcome measures
  • Design & analysis - use of routine data
  • Other methodological research