Section of Ophthalmology & Neuroscience

Led by Professor Chris Inglehearn

The aim of our research is to determine the causes of human inherited neurological disorders, and in so doing to gain insights into the processes of neurogenesis, neuronal homeostasis and function.

Research Areas

The aim of research in the Section of Ophthalmology and Neuroscience is to determine the causes of human inherited neurological disorders, and in so doing to gain insights into the processes of neurogenesis, neuronal homeostasis and function. The three sub-groups of the Vision Research Group study defects of the eye, while other members of the section have interests in Parkinson’s disease, microcephaly, mental retardation and a range of neurological and other deficits arising from defects of the cilia – the so called ciliopathies. Additional lines of research include investigating links between neurological defects and predisposition to cancer and between tooth and eye development.

The pathologies studied, together with the underlying pathways involved, are examined using the techniques of genetics, cell biology and proteomics analysis. A major strength is our access to patients and patient samples through links with and access to local clinicians, including geneticists and practitioners in ophthalmology, neurology, pathology, oral healthcare and other specialised areas, some of whom train for post-graduate research degrees in the laboratory. We also benefit from many national and international collaborations, and the Section now manages unique cohorts of patients’ DNA and cells for a number of diseases. Ultimately it is hoped that this research approach will contribute to the search for cures for both rare and common inherited human diseases.

Groups

Professor Chris Inglehearn (Section Head)
Vision Research Group; Retinal Dystrophies

Professor Colin Johnson
Ciliopathy Research Group

Dr Manir Ali
Vision Research Group; Anterior Segment Dysgenesis

Dr Sandra Bell
Microcephaly and Cancer Research Group 

Dr Jacquelyn Bond
Microcephaly and Neurogenesis Research Group 

Dr Alan Mighell
AI and Enamel Research Group 

Dr Ewan Morrison
Cell Biology Research Group

Dr Carmel Toomes
Vision Research Group; Retinal Vasculature