Research Projects


An acute bacterial skin and skin structure infection (ABSSSI) is a bacterial infection of the skin and surrounding tissues in which the area of affected skin is more than 75 square centimetres.  This study will help to improve understanding about the different medications that are currently used to treat ABSSSIs, the number of infections managed in real world practice and the impact on the healthcare system. 


Clinical management of Complicated intra-ABdominal Infection in United Kingdom hospitals


Pan-European Longitudinal Surveillance of Antibiotic Resistance among Prevalent Clostridium difficile Ribotypes - extended study


A Pilot randomised controlled single blind trial to compare standard single dose antibiotic prophylaxis administered as a bolus-continuous infusion for the prevention of surgical site infections in adults undergoing colorectal surgery

CPE Algorithm (HIS)

The collaborative project, led by Dr Caroline Chilton brings together experts from the University of Leeds, Leeds Teaching Hospitals NHS Trust and Public Health England to tackle the major problem of detection of antibiotic resistant organisms within the gut of healthy individuals.  It has been funded by a major research grant from the Healthcare Infection Society.


European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea


Retrospective data collection on patients with samples received during the EUropean, multicentre, prospective, biannual, point-prevalence study of CLostridium difficile Infection in hospitalised patients with diarrhoea

Fidaxomicin Transmission

Does fidaxomicin therapy reduce spread of Clostridium difficile

GlobalSurg II

Determining the worldwide epidemiology of Surgical Site Infections after Gastrointestinal Resection Surgery: A multicentre, international, prospective cohort study

GUT Model

Use of an in vitro human gut model to investigate Clostridium difficile infection


The projects seeks to translate the considerable potential and power offered by whole genome sequencing to revolutionise the diagnosis investigation and management of infection.

Home Guard

Antibiotic consumption and Enterobacteriaceae colonisation in hospitalised patients

Interactions within the Biofilm during CDI

The objective of this study is to understand the role that biofilms play in C. difficile infection and to increase our understanding of the microbial interactions within the biofilm.


A clinical trial to determine the efficacy of bacteriophages in the hospital setting


Longitudinal European Clostridium difficile Infection Diagnosis Surveillance study - Pilot study


Observational study of risk factors for Clostridium difficile infection in hospitalised patients with infective diarrhoea


To evaluate the lysin sampling, biosensors and readers on anonymised patients MRSA screening samples