Antibodies are the best-studied group of protein binding molecules to date, and have been successfully applied to a variety of biological and medical problems. They are particularly useful as therapeutics but in some applications their size and complexity can be limiting.
Alternative small, robust, easily manipulated non-antibody scaffolds provide a complementary technology for many molecular recognition solutions. These reagents can be selected to bind to, and block specific surfaces on target proteins and therefore have potential as molecular biology tools and therapeutic agents. As diagnostic tools they can be used for the detection and imaging of proteins in patient samples. The BSTG will screen for non-antibody binding probes against your target molecules by using phage display.