Division of Biomedical Imaging

The Division of Biomedical Imaging, headed by Professor Sven Plein, is a cutting edge multi-disciplinary research and teaching group dedicated to the development, clinical translation and clinical application of innovative biomedical imaging methods.

Supported by major grants from the British Heart Foundation, the Medical Research Council, the National Institute for Health Research and other funders, our objectives are to provide imaging solutions to improve the understanding of disease and ultimately improve patient care.

The division brings together experts in Medical Physics, Imaging Science, Clinical Imaging and Radiography. We have recognized expertise in depth-resolved optical imaging of cardiac-electrical activity and MRI and quantitative analysis of imaging data. In close collaboration with Chemistry in Leeds we develop novel contrast agents and Hyperpolarised MRI methods. We lead a large number of local and multi-centre trials and our key discoveries in cardiovascular MRI have informed national and international practice guidelines. We deliver a nationally leading Radiology teaching programme and Medical Imaging courses. 

Our world-class imaging facilities include a dedicated clinical MRI research facility with the latest generation 1.5T and 3T MRI scanners. A new state of the art preclinical imaging facility with high-field MRI, optical imaging, CT and PET/CT and a new National Centre for Hyperpolarised MRI will expand our existing imaging infrastructure from early 2016. These facilities will support major new translational imaging programmes and provide opportunities for researchers with experience in preclinical and molecular imaging.

Key Funding

Optimisation and validation of single-kidney GFR measurement with dynamic contrast-enhanced MRI
Kidney Research UK project grant

The purpose of this project is: (i) to optimise the analysis of these data to improve reproducibility and make it sufficiently practical for application in routine clinical practice; (ii) to validate the optimised method by comparison against the gold-standard and alternative DCE-MRI methods in a large existing study population; (iii) to support distribution, wider acceptance and transferability by development of a software prototype METHODS A database of 143 patient studies with paired MRI/radio-isotope data will be compiled by combining data from 4 previous studies.

Quantitative cardiac magnetic resonance for the evaluation of sub-clinical fibrosis and micro-vascular dysfunction in diabetic cardiomyopathy.
National Institute for Health Research (NIHR) PhD Research Fellowship

People  with  diabetes  mellitus  have  a  high  risk  of  developing  heart  failure.  This  risk  is  partly  due  to  diabetes  and  heart disease  sharing  some  risk  factors,  but  diabetes  also  causes  heart  wall  fibrosis,  contributing  to  the  development  of  heart failure.  This  work  aims  to  develop  and  test quantitative  magnetic  resonance  imaging  (MRI)  methods  for  measuring  the degree of heart muscle fibrosis. The methods will be tested in volunteers and patients with early and developed diabetes. They are expected to improve detection of heart wall damage in its early, potentially reversible, phase, allowing more timely treatment to prevent or delay development of heart failure.

2012-2017 BHF (SP/12/29062).
Greenwood (PI), Plein, Ball, Brown, Sculpher, McCann, Berry. Clinical Evaluation of 3T Magnetic Resonance imaging for the management of patients with Coronary heart disease
The CE-MARC 2 study. £1,177,145.

2012-2014 BHF. Greenwood(PI), Plein, McCann, Conway.
Cardiovascular MR evaluation of the safety and efficacy of Transcatheter Aortic Valve Implantation (TAVI) compared to surgical Aortic Valve Replacement (SAVR).
£233,754.

2013 – 2015 NIHR Doctoral Research Fellowship David Broadbent.
Quantitative cardiac magnetic resonance for the evaluation of sub-clinical fibrosis and microvascular dysfunction in diabetic cardiomyopathy.
£157,284.

Key Publications

2015

Garg P, Greenwood JP, Plein S.                                                                                                                      Multi-parametric relaxometry by cardiac magnetic resonance imaging in Takotsubo Cardiomyopathy. EHJ Cardiovascular Imaging. 2015 (in press).

Dobson LE, Fairbairn TA, Plein S, Greenwood JP.
Sex-related differences in aortic stenosis and its impact on outcome following surgical and transcatheter aortic valve replacement.
J Women's Health 2015; (in press)

Bulluck H, Fröhlich GM, Mohdnazri S, Gamma RA, Davies JR, Clesham GJ, Sayer JW, Aggarwal RK, Tang KH, Kelly PA, Jagathesan R, Kabir A, Robinson NM, Sirker A, Mathur A, Blackman DJ, Ariti C, Krishnamurthy A, White SK, Meier P, Moon JC, Greenwood JP, Hausenloy DJ.
Mineralocorticoid Receptor Antagonist Pretreatment to MINIMISE Reperfusion Injury After ST-Elevation Myocardial Infarction (The MINIMISE STEMI Trial): Rationale and Study Design.
Clin Cardiol. 2015; 38(5):259-66.

Broadbent DA, Biglands JD, Ripley DP, Higgins DM, Greenwood JP, Plein S, Buckley DL.
Sensitivity of quantitative myocardial dynamic contrast-enhanced MRI to saturation pulse efficiency, noise and t1 measurement error: Comparison of nonlinearity correction methods.
Magn Reson Med. 2015. [Epub ahead of print] 

Manisty C, Ripley DP, Herrey AS, Captur G, Wong TC, Petersen SE, Plein S, Peebles C, Schelbert EB, Greenwood JP, Moon JC.
Splenic Switch-off: A Tool to Assess Stress Adequacy in Adenosine Perfusion Cardiac MR Imaging
Radiology. 2015: 142059. [Epub ahead of print]
 

JN Khan, SA Nazir, MA Horsfield, A Singh, P Kanagala, JP Greenwood, AH Gershlick, GP McCann.
Comparison of semi-automated methods to quantify infarct size and myocardial salvage by cardiovascular magnetic resonance imaging at 1.5T and 3.0T field strengths.
BMC Res Notes 2015; 8:52.

DP Ripley, A K McDiarmid, A Kidambi, A Uddin, PP Swoboda, TA Musa, Bara Erhayiem, GJ Bainbridge, JP Greenwood, S Plein, DM Higgins.
Patient Adaptive Maximal Resolution Cardiovascular Magnetic Resonance Myocardial Stress Perfusion Imaging.
JMRI 2014; [Epub ahead of print]


AH Gershlick, J Khan, D Kelly, JP Greenwood, T Sasikaran, N Curzen, DJ Blackman, M Dalby, KL Fairbrother, W Banya, D Wang, M Flather, S Hetherington, AD Kelion, S Talwar, M Gunning, R Hall, H Swanton, G McCann.
Randomised trial of complete versus lesion only revascularisation in patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction and multi-vessel disease: The Complete versus Lesion-only Primary PCI Trial (CvLPRIT).
J Am Coll Cardiol 2015; 65(10):963-72.

A Uddin, TA Fairbairn, IK Djoukhader, M Igra, A Kidambi, M Motwani, B Herzog, DP Ripley, T Al Musa, AJP Goddard, DJ Blackman, S Plein, JP Greenwood.
Consequence of Cerebral Embolism following Transcatheter Aortic Valve Implantation (TAVI) compared to Contemporary Surgical Aortic Valve Replacement (SAVR): effect on Health Related Quality of Life.
Circ Cardiovasc Imaging 2015; 8(3) [Epub ahead of print]

McDiarmid AK, Swoboda PP, Erhayiem B, Ripley DP, Kidambi A, Broadbent DA, Higgins DM, Greenwood JP, Plein S.
Single bolus versus split dose gadolinium administration in extra-cellular volume calculation at 3 Tesla.
J Cardiovasc Magn Reson 2015;17(1):6.

M Motwani, A Kidambi, A Uddin, S Sourbron, JP Greenwood, S Plein.
Quantification of Myocardial Blood Flow with Cardiovascular Magnetic Resonance throughout the Cardiac Cycle.
J Cardiovasc Magn Reson 2015 17(1):4.

JD Biglands, DR Magee, SP Sourbron, S Plein, JP Greenwood, A Radjenovic.
Comparison of the diagnostic performance of four quantitative myocardial perfusion estimation methods used in cardiac MR imaging: CE-MARC substudy.
Radiology 2015; 275(2): 393-402.

DP Ripley, JM Brown, CC Everett, P Bijsterveld, S Walker, M Sculpher, GP McCann, C Berry, S Plein, JP Greenwood. Rationale and design of the Clinical Evaluation of MAgnetic Resonance imaging in Coronary heart disease 2 trial (CE-MARC 2): A prospective, multi-centre, randomized trial of diagnostic strategies in suspected coronary heart disease.
Am Heart J 2015; 169(1): 17-24.

AC Morton, AMK Rothman, JP Greenwood, J Gunn, A Chase, B Clarke, AS Hall, K Fox, C Foley, W Banya, D Wang, MD Flather, DC Crossman.
The effect of Interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: The MRC-ILA Heart Study.
European Heart Journal 2015; 36(6):377-84.


A Zaman, DM Higgins, M Motwani, A Kidambi, M Kouwenhoven, D Buckley, S Kozerke, JP Greenwood, S Plein.
Robust Myocardial T2 and T2* Mapping at 3T Using Image-based Shimming.
JMRI 2015; 41(4):1013-1020.

Biglands JD, Magee DR, Sourbron SP, Plein S, Greenwood JP, Radjenovic A.
Comparison of the Diagnostic Performance of Four Quantitative Myocardial Perfusion Estimation Methods Used in Cardiac MR Imaging: CE-MARC Substudy.
Radiology 2015;275(2):393-402.

Sourbron S.
A Tracer-Kinetic Field Theory for Medical Imaging.
IEEE T Med Imaging 2014;33(4):935-946.

Gislason-Lee AJ, McMillan C, Cowen AR, Davies AG.
Dose optimization in cardiac x-ray imaging.
Med Phys 2013;40(9).

Lim SW, Chrysochou C, Buckley DL, Kalra PA, Sourbron SP.
Prediction and assessment of responses to renal artery revascularization with dynamic contrast-enhanced magnetic resonance imaging: a pilot study.
Am J Physiol-Renal 2013;305(5):F672-F678.

Broadbent DA, Biglands JD, Larghat A, Sourbron SP, Radjenovic A, Greenwood JP, Plein S, Buckley DL.
Myocardial Blood Flow at Rest and Stress Measured with Dynamic Contrast-Enhanced MRI: Comparison of a Distributed Parameter Model with a Fermi Function Model.
Magnetic Resonance in Medicine 2013;70(6):1591-1597.

Sourbron S, Sommer WH, Reiser MF, Zech CJ.
Combined quantification of liver perfusion and function with dynamic gadoxetic acid-enhanced MR imaging.
Radiology 2012;263(3):874-883.

Staff

Mrs.Amber Gislason-Lee- A.J.GISLASON@LEEDS.AC.UK- Research Assistant

Mr.Andrew Davies- A.G.Davies@leeds.ac.uk- Lecturer

Dr.Anita Banerji- A.BANERJI@LEEDS.AC.UK- Research Fellow

Dr.Arshad Zaman- A.ZAMAN@LEEDS.AC.UK- Research Fellow

Dr.Bara Erhayiem- B.ERHAYIEM@LEEDS.AC.UK- Clinical Research Fellow

Dr.Charalampos Tsoumpas- C.TSOUMPAS@LEEDS.AC.UK- Lecturer in Medical Imaging

Professor.David Buckley- D.L.BUCKLEY@LEEDS.AC.UK- Professor

Dr.David Ripley- D.RIPLEY@LEEDS.AC.UK- Research Fellow

Dr.James Foley- J.FOLEY@LEEDS.AC.UK- Clinical Research Fellow

Professor.John Greenwood- J.Greenwood@leeds.ac.uk- Professor (Clinical)

Dr.Joseph Evans- J.A.EVANS@LEEDS.AC.UK- Senior Lecturer

Dr.Laura Dobson- L.DOBSON@LEEDS.AC.UK- Clinical Research Fellow

Dr.Laura Treadgold- L.A.Rhodes@leeds.ac.uk- Lecturer in Medical Physics

Mr.Leonidas Georgiou- L.GEORGIOU@LEEDS.AC.UK- Research Fellow

Dr.Pankaj Garg- P.GARG@LEEDS.AC.UK- Clinical Research Fellow

Dr.Peter Swoboda- P.SWOBODA@LEEDS.AC.UK- Clinical Research Fellow

Professor.Sven Plein- S.PLEIN@LEEDS.AC.UK- Professor of Cardiology (Clinical)

Dr.Tarique Al Musa- T.A.MUSA@LEEDS.AC.UK- Clinical Research Fellow