Optimisation and validation of single-kidney GFR measurement with dynamic contrast-enhanced MRI
Kidney Research UK project grant
The purpose of this project is: (i) to optimise the analysis of these data to improve reproducibility and make it sufficiently practical for application in routine clinical practice; (ii) to validate the optimised method by comparison against the gold-standard and alternative DCE-MRI methods in a large existing study population; (iii) to support distribution, wider acceptance and transferability by development of a software prototype METHODS A database of 143 patient studies with paired MRI/radio-isotope data will be compiled by combining data from 4 previous studies.
Quantitative cardiac magnetic resonance for the evaluation of sub-clinical fibrosis and micro-vascular dysfunction in diabetic cardiomyopathy.
National Institute for Health Research (NIHR) PhD Research Fellowship
People with diabetes mellitus have a high risk of developing heart failure. This risk is partly due to diabetes and heart disease sharing some risk factors, but diabetes also causes heart wall fibrosis, contributing to the development of heart failure. This work aims to develop and test quantitative magnetic resonance imaging (MRI) methods for measuring the degree of heart muscle fibrosis. The methods will be tested in volunteers and patients with early and developed diabetes. They are expected to improve detection of heart wall damage in its early, potentially reversible, phase, allowing more timely treatment to prevent or delay development of heart failure.
2012-2017 BHF (SP/12/29062).
Greenwood (PI), Plein, Ball, Brown, Sculpher, McCann, Berry. Clinical Evaluation of 3T Magnetic Resonance imaging for the management of patients with Coronary heart disease
The CE-MARC 2 study. £1,177,145.
2012-2014 BHF. Greenwood(PI), Plein, McCann, Conway.
Cardiovascular MR evaluation of the safety and efficacy of Transcatheter Aortic Valve Implantation (TAVI) compared to surgical Aortic Valve Replacement (SAVR).
2013 2015 NIHR Doctoral Research Fellowship David Broadbent.
Quantitative cardiac magnetic resonance for the evaluation of sub-clinical fibrosis and microvascular dysfunction in diabetic cardiomyopathy.
Garg P, Greenwood JP, Plein S. Multi-parametric relaxometry by cardiac magnetic resonance imaging in Takotsubo Cardiomyopathy. EHJ Cardiovascular Imaging. 2015 (in press).
Dobson LE, Fairbairn TA, Plein S, Greenwood JP.
Sex-related differences in aortic stenosis and its impact on outcome following surgical and transcatheter aortic valve replacement.
J Women's Health 2015; (in press)
Bulluck H, Fröhlich GM, Mohdnazri S, Gamma RA, Davies JR, Clesham GJ, Sayer JW, Aggarwal RK, Tang KH, Kelly PA, Jagathesan R, Kabir A, Robinson NM, Sirker A, Mathur A, Blackman DJ, Ariti C, Krishnamurthy A, White SK, Meier P, Moon JC, Greenwood JP, Hausenloy DJ.
Mineralocorticoid Receptor Antagonist Pretreatment to MINIMISE Reperfusion Injury After ST-Elevation Myocardial Infarction (The MINIMISE STEMI Trial): Rationale and Study Design.
Clin Cardiol. 2015; 38(5):259-66.
Broadbent DA, Biglands JD, Ripley DP, Higgins DM, Greenwood JP, Plein S, Buckley DL.
Sensitivity of quantitative myocardial dynamic contrast-enhanced MRI to saturation pulse efficiency, noise and t1 measurement error: Comparison of nonlinearity correction methods.
Magn Reson Med. 2015. [Epub ahead of print]
Manisty C, Ripley DP, Herrey AS, Captur G, Wong TC, Petersen SE, Plein S, Peebles C, Schelbert EB, Greenwood JP, Moon JC.
Splenic Switch-off: A Tool to Assess Stress Adequacy in Adenosine Perfusion Cardiac MR Imaging
Radiology. 2015: 142059. [Epub ahead of print]
JN Khan, SA Nazir, MA Horsfield, A Singh, P Kanagala, JP Greenwood, AH Gershlick, GP McCann.
Comparison of semi-automated methods to quantify infarct size and myocardial salvage by cardiovascular magnetic resonance imaging at 1.5T and 3.0T field strengths.
BMC Res Notes 2015; 8:52.
DP Ripley, A K McDiarmid, A Kidambi, A Uddin, PP Swoboda, TA Musa, Bara Erhayiem, GJ Bainbridge, JP Greenwood, S Plein, DM Higgins.
Patient Adaptive Maximal Resolution Cardiovascular Magnetic Resonance Myocardial Stress Perfusion Imaging.
JMRI 2014; [Epub ahead of print]
AH Gershlick, J Khan, D Kelly, JP Greenwood, T Sasikaran, N Curzen, DJ Blackman, M Dalby, KL Fairbrother, W Banya, D Wang, M Flather, S Hetherington, AD Kelion, S Talwar, M Gunning, R Hall, H Swanton, G McCann.
Randomised trial of complete versus lesion only revascularisation in patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction and multi-vessel disease: The Complete versus Lesion-only Primary PCI Trial (CvLPRIT).
J Am Coll Cardiol 2015; 65(10):963-72.
A Uddin, TA Fairbairn, IK Djoukhader, M Igra, A Kidambi, M Motwani, B Herzog, DP Ripley, T Al Musa, AJP Goddard, DJ Blackman, S Plein, JP Greenwood.
Consequence of Cerebral Embolism following Transcatheter Aortic Valve Implantation (TAVI) compared to Contemporary Surgical Aortic Valve Replacement (SAVR): effect on Health Related Quality of Life.
Circ Cardiovasc Imaging 2015; 8(3) [Epub ahead of print]
McDiarmid AK, Swoboda PP, Erhayiem B, Ripley DP, Kidambi A, Broadbent DA, Higgins DM, Greenwood JP, Plein S.
Single bolus versus split dose gadolinium administration in extra-cellular volume calculation at 3 Tesla.
J Cardiovasc Magn Reson 2015;17(1):6.
M Motwani, A Kidambi, A Uddin, S Sourbron, JP Greenwood, S Plein.
Quantification of Myocardial Blood Flow with Cardiovascular Magnetic Resonance throughout the Cardiac Cycle.
J Cardiovasc Magn Reson 2015 17(1):4.
JD Biglands, DR Magee, SP Sourbron, S Plein, JP Greenwood, A Radjenovic.
Comparison of the diagnostic performance of four quantitative myocardial perfusion estimation methods used in cardiac MR imaging: CE-MARC substudy.
Radiology 2015; 275(2): 393-402.
DP Ripley, JM Brown, CC Everett, P Bijsterveld, S Walker, M Sculpher, GP McCann, C Berry, S Plein, JP Greenwood. Rationale and design of the Clinical Evaluation of MAgnetic Resonance imaging in Coronary heart disease 2 trial (CE-MARC 2): A prospective, multi-centre, randomized trial of diagnostic strategies in suspected coronary heart disease.
Am Heart J 2015; 169(1): 17-24.
AC Morton, AMK Rothman, JP Greenwood, J Gunn, A Chase, B Clarke, AS Hall, K Fox, C Foley, W Banya, D Wang, MD Flather, DC Crossman.
The effect of Interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: The MRC-ILA Heart Study.
European Heart Journal 2015; 36(6):377-84.
A Zaman, DM Higgins, M Motwani, A Kidambi, M Kouwenhoven, D Buckley, S Kozerke, JP Greenwood, S Plein.
Robust Myocardial T2 and T2* Mapping at 3T Using Image-based Shimming.
JMRI 2015; 41(4):1013-1020.
Biglands JD, Magee DR, Sourbron SP, Plein S, Greenwood JP, Radjenovic A.
Comparison of the Diagnostic Performance of Four Quantitative Myocardial Perfusion Estimation Methods Used in Cardiac MR Imaging: CE-MARC Substudy.
A Tracer-Kinetic Field Theory for Medical Imaging.
IEEE T Med Imaging 2014;33(4):935-946.
Gislason-Lee AJ, McMillan C, Cowen AR, Davies AG.
Dose optimization in cardiac x-ray imaging.
Med Phys 2013;40(9).
Lim SW, Chrysochou C, Buckley DL, Kalra PA, Sourbron SP.
Prediction and assessment of responses to renal artery revascularization with dynamic contrast-enhanced magnetic resonance imaging: a pilot study.
Am J Physiol-Renal 2013;305(5):F672-F678.
Broadbent DA, Biglands JD, Larghat A, Sourbron SP, Radjenovic A, Greenwood JP, Plein S, Buckley DL.
Myocardial Blood Flow at Rest and Stress Measured with Dynamic Contrast-Enhanced MRI: Comparison of a Distributed Parameter Model with a Fermi Function Model.
Magnetic Resonance in Medicine 2013;70(6):1591-1597.
Sourbron S, Sommer WH, Reiser MF, Zech CJ.
Combined quantification of liver perfusion and function with dynamic gadoxetic acid-enhanced MR imaging.
Dr.Arshad Zaman- A.ZAMAN@LEEDS.AC.UK- Research Fellow
Dr.David Ripley- D.RIPLEY@LEEDS.AC.UK- Research Fellow
Dr.James Foley- J.FOLEY@LEEDS.AC.UK- Clinical Research Fellow
Dr.Joseph Evans- J.A.EVANS@LEEDS.AC.UK- Senior Lecturer
Dr.Laura Dobson- L.DOBSON@LEEDS.AC.UK- Clinical Research Fellow
Mr.Leonidas Georgiou- L.GEORGIOU@LEEDS.AC.UK- Research Fellow
Dr.Pankaj Garg- P.GARG@LEEDS.AC.UK- Clinical Research Fellow
Dr.Peter Swoboda- P.SWOBODA@LEEDS.AC.UK- Clinical Research Fellow
Dr.Tarique Al Musa- T.A.MUSA@LEEDS.AC.UK- Clinical Research Fellow