The Faculty of Medicine & Health has a broad range of excellence in basic biomedical research, with complementary expertise in other faculties at the University and an outstanding track record in clinical and medical genetics, cardiovascular and musculoskeletal diseases (including Dental) and cancer research. The partnership between the University of Leeds and the Leeds Teaching Hospitals NHS Trust has led the sector in the development of clinical diagnostic testing based on next generation sequencing. The elucidation of molecular mechanisms of pathogenesis remains an important challenge for many disciplines, requiring functional and structural information at a molecular level and, in turn, allowing the identification of potential therapeutic targets and innovations in medical technologies. Translating these discoveries to maximise the impact of our basic sciences entails the creation and validation of in vitro cellular models and pre-clinical animal models, pre-clinical pharmacology, as well as phenotyping and in vivo physiological studies in patients and first-in-man studies. These pathways are common across all our discipline areas of excellence where we aim to under-pin high quality translational research for patient benefit with world class basic and applied science.  We have enhanced our capacity in structural biology through the development of strong links with the Astbury Centre, within the Faculty of Biological Sciences, an internationally recognized centre of excellence. A focus on cross-Faculty and multidisciplinary collaborations is a priority, and we continue to utilise our excellent clinical facilities. We are developing our basic biomedical research across all our discipline areas, including the use of animal models to verify target and function; development of cell systems to investigate function; development of in vitro systems to verify target and function; identification of inhibitors of protein function and verification of target; pre-clinical pharmacology, design of biomimetic devices/materials and capacity building our CRF portfolio.

Lead Academics:
Professor Colin A. Johnson, tel: +44 (0) 113 3438443, email: C.Johnson@leeds.ac.uk 
Professor Jennifer Kirkham, tel: +44 (0) 113 3436156, email: J.Kirkham@leeds.ac.uk 
Professor Robert Ariens, tel: +44 (0) 113 3437734, email: R.A.S.Ariens@leeds.ac.uk