ALPHA: ALitretinoin versus PUVA in severe chronic HAnd eczema trial

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Alpha logoThe ALPHA trial compares Alitretinoin and PUVA therapy in patients aged 18 years and over with severe hand eczema which is not controlled on a daily (regular) basis with prescription steroid creams.



November 2017:

  1. November has been a great month. We now have 330 participants registered and 232 participants randomised to the trial! Thank you to everyone taking part
  2. Great news: ALPHA recruitment will continue for a further 22 months until the end of January 2020. Many thanks to all our participating sites for all their hard work and dedication to the trial
  3. Did you know November is #NationalHealthySkinMonth this month?

October 2017:

  1. We are pleased to announce that Debbie Hukins has joined the CTRU as the ALPHA Senior Trial Coordinator - welcome to team! Her contact details are below so please don't hesitate to contact her if you need further information about ALPHA
  2. Victoria Goss, our ALPHA STC, is taking a break from the CTRU while she concentrates more on family life - we can't wait to meet the new addition to your family!
  3. We now have 300 participants registered! Thank you to everyone taking part

September 2017:  

  1. Don’t forget it’s #NationalEczemaWeek this month!

  2. We now have 280 participants registered and 210 participants randomised! Congratulations to all the teams at our participating hospitals 

BBC Look North (Yorkshire) features Dr Miriam Wittmann discussing the ALPHA trial - click the link ( to watch the full programme. Here's a shortened version of the video on the BBC Look North face book page:


For earlier news feed items please go here

Want to know more?

Alpha patient zone 4Alpha hospitalsAlpha potential investigators

If you can't find a hospital near you, please keep checking regularly as more hospitals will be added as they are opened to recruitment.

Contact us

Are you a hospital based clinician who would like to take part in the ALPHA trial?  

Are you a research active GP practice? Would you like to refer patients with severe chronic hand eczema to a local ALPHA participating hospital?

If so, please contact Debbie Hukins, Senior Trial Coordinator for more details:

Debbie Hukins
Senior Trial Coordinator
Tel: 0113 343 4317


Hand eczema, hand dermatitis, clinical trial, ALPHA, research, Alitretinoin, PUVA, GP, NHS, NIHR HTA

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Pages in this document

  1. ALPHA: ALitretinoin versus PUVA in severe chronic HAnd eczema trial
  2. Earlier news from the ALPHA trial