ALPHA: ALitretinoin versus PUVA in severe chronic HAnd eczema trial

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Alpha logoThe ALPHA trial compares Alitretinoin and PUVA therapy in patients aged 18 years and over with severe hand eczema which is not controlled on a daily (regular) basis with prescription steroid creams.



July 2018:

  1. Happy 70th birthday to our NHS - Leeds CTRU couldn't run the high quality academic clinical trials which influence national and international clinical practice without all the committed, hard working, caring nurses and consultants. A BIG thank you to all our participating sites for your hard work and dedication to this trial.

June 2018:

  1. Well done to the research teams at Ninewells hospital Dundee, Queen Elizabeth University Hospitals Glasgow, Broadgreen Hospital Liverpool, and Royal Victoria Infirmary Newcastle for being the top ALPHA sites for registering participants this month.
  2. Well done to the research team at Chapel Allerton Hospital Leeds for being the top ALPHA site for randomising participants this month.

May 2018:

  1. New ALPHA dedicated telephone number (01274 365 163) available as an alternative to website self referrals - see ALPHA Self-Screening Questionnaire page for details
  2. We are pleased to announce that Fiona Brudenell Straw has joined the CTRU as the ALPHA Senior Trial Coordinator - welcome to team! Her contact details are below so please don't hesitate to contact her if you need further information about ALPHA

BBC Look North (Yorkshire) features Dr Miriam Wittmann discussing the ALPHA trial - click the link ( to watch the full programme. Here's a shortened version of the video on the BBC Look North face book page:


For earlier news feed items please go here

Want to know more?

Alpha patient zone 4Alpha hospitalsAlpha potential investigators

If you can't find a hospital near you, please keep checking regularly as more hospitals will be added as they are opened to recruitment.

Contact us

Are you a hospital based clinician who would like to take part in the ALPHA trial?  

Are you a research active GP practice? Would you like to refer patients with severe chronic hand eczema to a local ALPHA participating hospital?

If so, please contact Fiona Brudenell Straw, Senior Trial Coordinator for more details:

Fiona Brudenell Straw
Senior Trial Coordinator
Tel: 0113 343 4317


Hand eczema, hand dermatitis, clinical trial, ALPHA, research, Alitretinoin, PUVA, GP, NHS, NIHR HTA

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Pages in this document

  1. ALPHA: ALitretinoin versus PUVA in severe chronic HAnd eczema trial
  2. Earlier news from the ALPHA trial